The aim was to determine the relationship among alcohol use, different socio-demographic variables, tobacco use and physical exercise practice in adults from three provinces of southern of Spain. A representative sample of 3373 participants from Almeria, Granada and Murcia, with ages between 16 and 96 year-old, participated in the present study. They completed the questionnaire "Sport-physical habits and lifestyles". It was found alcohol use was significantly influenced by various family members' and the couple's alcohol habits. The physical and sport practice in adults was not a protective factor for alcohol use, because there were who had never practiced physical exercise and who had abandoned the regular practice of physical exercise which had less probability of drink alcohol regularly or sporadically. However, who had never practiced physical exercise and who had abandoned the regular practice of physical exercise were which showed a high probability (up to twice the risk) to have a risk or a high-risk consumption in terms of the quantity of alcohol drinking. In addition, the data indicated the consumption of tobacco was a significant predisposing factor for the consumption of alcohol.