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Japanese Society of Internal Medicine, Internal Medicine, 11(53), p. 1159-1164, 2014

DOI: 10.2169/internalmedicine.53.1137

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Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the <i>FLT3-ITD</i> Mutation

Journal article published in 2014 by Yusuke Isshiki, Chikako Ohwada, Emi Togasaki, Ryoh Shimizu, Nagisa Hasegawa, Atsuko Yamazaki, Yasumasa Sugita, Takeharu Kawaguchi, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Masahiro Takeuchi ORCID, Emiko Sakaida, Naomi Shimizu, Satoshi Ota and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.