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Elsevier, Clinical Neurophysiology, 2(127), p. 1645-1651

DOI: 10.1016/j.clinph.2015.10.047

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Non-invasive measurement of baroreflex during Valsalva maneuver: Evaluation of alpha and beta-adrenergic components

Journal article published in 2015 by Iryna S. Palamarchuk, Jacquie Baker, Kurt Kimpinski ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Objective: To evaluate alpha and beta components of adrenergic baroreflex sensitivity (BRSa) in Valsalva maneuver (VM). Methods: BRSa was studied in 89 healthy subjects aged 30±13 [16-75] years. Subjects were divided into three groups per blood pressure (BP) patterns associated with relatively balanced or increased alpha-adrenergic modulation: (1) BAR (n =43) - Balanced Autonomic Response with a BP dip below baseline in late phase II (IIL) and recovery in phase IV; (2) SAR (n =16) - Suppressed Autonomic Response with a non-dipping BP; and (3) AAR (n =30) - Augmented Autonomic Response with a BP recovery in phase IIL. Discrete (alpha and beta) BRSa formulae were produced using alpha- or beta-adrenergic phases: α-BRSa (phase IIL) and β-BRSa (phase IV), respectively. Discrete BRSa were studied to determine potential correlations to BRSa1 (validated BRSa evaluation) and evaluated for reliability. Results: Patterns with higher α-adrenergic influence showed correlation between α-BRSa and BRSa1 (AAR: r =0.447, p <0.05; SAR: r =0.774, p <0.01). BAR showed correlation between β-BRSa and BRSa1 (r =-0.566, p <0.01), and α- and β-adrenergic coefficients (r =-0.381, p <0.05). Discrete BRSa were more reliable than BRSa1 (n =33; p <0.05). Conclusions: Discrete BRSa are reproducible and correlated with BRSa1. Significance: If validated, discrete BRSa may differentiate physiologic variances and vague dysautonomia.