Links

Tools

Export citation

Search in Google Scholar

RNA Polymerase II Elongation at the Crossroads of Transcription and Alternative Splicing

Journal article published in 2011 by Manuel de la Mata, Manuel J. Muñoz, Mariano Alló, Juan Pablo Fededa, Ignacio E. Schor, Alberto R. Kornblihtt ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload

Abstract

The elongation phase of transcription lies at the core of several simultaneous and coupled events leading to alternative splicing regulation. Although underestimated in the past, it is at this phase of the transcription cycle where complexes affecting the transcription machinery itself, chromatin structure, posttranscriptional gene regulation and pre-mRNA processing converge to regulate each other or simply to consolidate higher-order complexes and functions. This paper focuses on the multiple processes that take place during transcription elongation which ultimately regulate the outcome of alternative splicing decisions.