Optimism, self-esteem, satisfaction with social support, and coping strategies were examined in relation to study-related subjective workload, stress, and life satisfaction. Questionnaires were distributed to students in the second, third, and fourth years of the five-year BVSc program at Massey University. One hundred fifty usable responses were received. Most respondents were female. Students with more optimism and self-esteem were less stressed than those who were more pessimistic or lower in self-esteem. Students who reported having heavy subjective workloads were more stressed, whereas students with higher self-esteem experienced more well-being. Men and women did not differ on any of the study variables, and there were no differences between students in different years of study. Recommendations include retaining initiatives to build well-being that are already in place. Support resources exist within the university, but students are often reluctant to seek help, so staff need to continue to identify students in need of additional help who might benefit from referral to a health practitioner. Where practicable, support service providers may be able to contribute actively to teaching. As well as helping students build effective social and coping strategies, this approach will provide students with additional information about the services that are available. Students may not see workshops on interpersonal skills or stress management as relevant unless they are linked to their immediate concerns.