The objective of this study was to assess hemodynamic responses and baroreflex sensitivity (BRS) indexes during Valsalva maneuver (VM) and head-up tilt (HUT) testing in orthostatic intolerance (OI). Patients with neurogenic orthostatic hypotension (NOH, n = 26), postural tachycardia syndrome ( n = 26) and symptomatic OI ( n = 14) were compared with healthy population (control, n = 107) and inappropriate sinus tachycardia ( n = 7). Hemodynamic assessment included patterning and quantification with vagal and adrenergic BRS (BRSa/BRSa₁). In NOH, cardiovagal systolic blood pressure (SBP) decrements in VM and HUT were correlated ( r = 0.660, P < 0.001); a “V” pattern of VM indicated α-BRSa failure. Yet BRSa₁ did not reveal changes vs. control ( P > 0.05) or was not applicable in 60% of NOH. In symptomatic OI, compared with control, cardiovagal SBP decrements were larger ( P < 0.05); higher BRSa₁ contradicted higher adrenergic index (Composite Autonomic Severity Score). Overshoot in phase IV dipped below baseline or dropped ≥ 10 mmHg over 8 s in postural tachycardia syndrome (“N” pattern), but by 3 s in inappropriate sinus tachycardia (“M” pattern). Visualization of distinct VM patterns allows primary evaluation of autonomic dysfunction and differentiation of the various forms of OI. BRSa₁ evaluation is compromised by pathological SBP patterns. VM patterning is a valuable nonpostural supplement to HUT capable of detecting and differentiating OI.