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BioMed Central, BMC Medicine, 1(14), 2016

DOI: 10.1186/s12916-016-0570-1

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HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies

Journal article published in 2016 by Ben Schöttker ORCID, W. Rathmann, C. Herder, B. Thorand, T. Wilsgaard, I. Njølstad, G. Siganos, E. B. Mathiesen, K. U. Saum, A. Peasey, E. Feskens, P. Boffetta, A. Trichopoulou, K. Kuulasmaa, F. Kee and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations. Methods The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six population-based cohort studies from Europe and the USA and meta-analyzed. Very low, low, intermediate and increased HbA1c were defined as