Published in
BioMed Central, BMC Medicine, 1(14), 2016
DOI: 10.1186/s12916-016-0570-1
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HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies
,
W. Rathmann,
C. Herder,
B. Thorand,
T. Wilsgaard,
I. Njølstad,
G. Siganos,
E. B. Mathiesen,
K. U. Saum,
A. Peasey,
E. Feskens,
P. Boffetta,
A. Trichopoulou,
K. Kuulasmaa,
F. Kee
and other authors.
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Abstract
Abstract Background To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations. Methods The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six population-based cohort studies from Europe and the USA and meta-analyzed. Very low, low, intermediate and increased HbA1c were defined as