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EMBO Press, The EMBO Journal, 10(33), p. 1087-1088, 2014

DOI: 10.1002/embj.201488178

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Precision attack on calcineurin in macrophages: A new anti-inflammatory weapon

Journal article published in 2014 by Joachim L. Schultze ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Inflammation is a hallmark of many common diseases ranging from arthritis, atherosclerosis, or obesity to Alzheimer's disease and cancer. Identifying anti-inflammatory mechanisms is therefore an important and timely task of modern biomedicine. In this issue of The EMBO Journal, a study conducted by Escolano and colleagues target a particular interaction site of calcineurin with NFAT in macrophages to elicit profound anti-inflammatory effects (Escolano et al, 2014). Peptide-based targeting of a unique calcineurin/NFAT interaction site in macrophages reveals anti-inflammatory potential for various major diseases.