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Ferrata Storti Foundation, Haematologica

DOI: 10.3324/haematol.2015.139626

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Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity

Journal article published in 2016 by Richard J. Bende ORCID, Jerry Janssen, Thera A. M. Wormhoudt, Koen Wagner, Jeroen E. J. Guikema, Carel J. M. van Noesel
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Subsets of mucosa-associated lymphoid tissue (MALT) lymphoma, splenic marginal zone B-cell lymphoma (MZBCL) and chronic lymphocytic leukemia (CLL) have been identified that express near-identical B-cell receptors (BCRs), strongly suggesting selection by restricted antigenic epitopes. We here report a new IGV mutated stereotypic IGHV4-59/IGHJ5-encoded BCR subset, expressed in hepatitis C virus (HCV)-related B-cell lymphoma, MALT lymphoma and diffuse large B-cell lymphoma (DLBCL). We demonstrate that these mutated stereotypic IGHV4-59/IGHJ5 BCRs are high affinity monoreactive rheumatoid factors (RFs) underscoring the significance of IgG as a major auto-antigen in the pathogenesis of several types of B-cell lymphoma.