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Springer, Human Genetics, 3(135), p. 299-307, 2016

DOI: 10.1007/s00439-016-1633-2

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A genome-wide association study of pulmonary tuberculosis in Morocco

Journal article published in 2016 by A. V. Grant, A. Sabri, A. Abid, I. Abderrahmani Rhorfi, I. Abderrahmani Rhorfi, M. Benkirane, H. Souhi, H. Naji Amrani, H. Naji Amrani, K. Alaoui Tahiri, Y. Gharbaoui, F. Lazrak, I. Sentissi, M. Manessouri, S. Belkheiri and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Although epidemiological evidence suggests a human genetic basis of pulmonary tuberculosis (PTB) susceptibility, the identification of specific genes and alleles influencing PTB risk has proven to be difficult. Previous genome-wide association (GWA) studies have identified only three novel loci with modest effect sizes in sub-Saharan African and Russian populations. We performed a GWA study of 550,352 autosomal SNPs in a family-based discovery Moroccan sample (on the full population and on the subset with PTB diagnosis at