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Nature Research, Nature, 7538(518), p. 197-206

DOI: 10.1038/nature14177

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Genetic studies of body mass index yield new insights for obesity biology

Journal article published in 2015 by Johan Ärnl, Ferdinand M. van ’t Hooft, Sophie W. van Wingerden, W. Zhang, Weihua Zhang, Wh Zhang, Qunyuan Zhang, Qy Zhang, Tune H. Pers, Adam E. Locke ORCID, Ferdinand M. van 't Hooft, Hester M. den Ruijter, Sonja I. Berndt, Bratati Kahali, Å. K. Hedman and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.