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Nature Research, Nature Communications, 1(7), 2016

DOI: 10.1038/ncomms10513

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Phylogenomic and biogeographic reconstruction of the Trichinella complex

Journal article published in 2016 by Pasi K. Korhonen, Edoardo Pozio, Giuseppe La Rosa, Bill C. H. Chang, Anson V. Koehler, Eric P. Hoberg, Peter R. Boag, Patrick Tan, Andreas Hofmann ORCID, Aaron R. Jex, Paul W. Sternberg ORCID, Robin B. Gasser, Neil D. Young ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractTrichinellosis is a globally important food-borne parasitic disease of humans caused by roundworms of the Trichinella complex. Extensive biological diversity is reflected in substantial ecological and genetic variability within and among Trichinella taxa, and major controversy surrounds the systematics of this complex. Here we report the sequencing and assembly of 16 draft genomes representing all 12 recognized Trichinella species and genotypes, define protein-coding gene sets and assess genetic differences among these taxa. Using thousands of shared single-copy orthologous gene sequences, we fully reconstruct, for the first time, a phylogeny and biogeography for the Trichinella complex, and show that encapsulated and non-encapsulated Trichinella taxa diverged from their most recent common ancestor ∼21 million years ago (mya), with taxon diversifications commencing ∼10−7 mya.