Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

van der Klauw, M. M.; van Vliet-Ostaptchouk, J.; Berndt, Sonja I.; Gustafsson, Stefan; Mägi, Reedik; Ganna, Andrea; Wheeler, Eleanor; Feitosa, Mary F.; Justice, Anne E.; Monda, Keri L.; Maegi, Reedik; Croteau-Chonka, Damien C.; Day, Felix R.; Esko, Tõnu; E., Anne; Fall, Tove; Ferreira, Teresa; Gentilini, Davide; Ae, Justice; Jackson, Anne U.; Randall, Joshua C.; Vedantam, Sailaja; Magi, R.; Willer, Cristen J.; Mägi, Reedik; Winkler, Thomas W.; Wood, Andrew R.; Workalemahu, Tsegaselassie; Hu, Yi-Juan; Lee, Sang Hong; Luan, Jian An; Liang, Liming M.; Lin, Dan-Yu; Min, Josine L.; Neale, Benjamin M.; Thorleifsson, Gudmar; A. E., Justice; Yang, Jian; Albrecht, Eva; Amin, Najaf; Bragg-Gresham, Jennifer L.; Cadby, Gemma; den Heijer, Martin; Klauw, Melanie M.; Eklund, Niina; Fischer, Krista; Goel, Anuj; Hottenga, Jouke-Jan; Johansson, Åsa; Huffman, Jennifer E.; Jarick, Ivonne; Johansson, Åsa; Johnson, Toby; Kanoni, Stavroula; Johansson, Å.; Kleber, Marcus E.; König, Inke R.; Kristiansson, Kati; Heijer, Martin den; Lamina, Claudia; Müller-Nurasyid, Martina; Lecoeur, Cecile; Li, Guo; Mangino, Massimo; McArdle, Wendy L.; Medina-Gomez, Carolina; Koenig, Inke R.; Müller-Nurasyid, Martina; Ngwa, Julius S.; Nolte, Ilja M.; Paternoster, Lavinia; Pechlivanis, Sonali; Kutalik, Zoltn; Perola, Markus; Peters, Marjolein J.; Preuss, Michael; Rose, Lynda M.; Shi, Jianxin X.; Muller-Nurasyid, M.; Shungin, Dmitry; Smith, Albert Vernon; Strawbridge, Rona J.; Surakka, Ida; Teumer, Alexander; Lavinia, P.; Trip, Mieke D.; Tyrer, Jonathan; Mueller-Nurasyid, Martina; Vandenput, Liesbeth; Waite, Lindsay Ll; Meurs, Joyce B. J.; Zhao, Jing Hua; Absher, Devin; Asselbergs, Folkert W.; Atalay, Mustafa; Attwood, Antony P.; König, Inke R.; Balmforth, Anthony J.; Basart, Hanneke; Beilby, John; Bonnycastle, Lori Ll; Brambilla, Paolo; Van Vliet-Ostaptchouk, Jv; Bruinenberg, Marcel; Campbell, Harry; Chasman, Daniel I.; Chines, Peter S.; Collins, Francis S.; Van, J. V.; Connell, John M.; Cookson, William O.; de Faire, Ulf; de Vegt, Femmie; Dei, Mariano; Duijn, Cornelia M.; Dimitriou, Maria; Edkins, Sarah; Estrada, Karol; Evans, David M.; Farrall, Martin; Van Vliet-Ostaptchouk, Jana V.; Ferrario, Marco Mm; Ferrieres, Jean; Franke, Lude; Frau, Francesca; Gejman, Pablo V.; Groenberg, Henrik; Grallert, Harald; Grönberg, Henrik; Gudnason, Vilmundur; Hall, Alistair S.; Gronberg, H.; Hall, Per; Hartikainen, Anna-Liisa; Hayward, Caroline; Heard-Costa, Nancy L.; Heath, Andrew C.; König, Wolfgang; Hebebrand, Johannes; Homuth, Georg; Hu, Frank B.; Hunt, Sarah E.; Hyppönen, Elina; Hyppoenen, Elina; Iribarren, Carlos; Jacobs, Kevin B.; Jansson, John-Olov; Jula, Antti; Kähönen, Mika; Koenig, Wolfgang; Kathiresan, Sekar; Kee, Frank; Khaw, Kay-Tee; Kivimaki, Mika; O. Cookson, W.; De Faire, U.; Kraja, Aldi T.; Kumari, Meena; Kuulasmaa, Kari; Kuusisto, Johanna; Laitinen, Jaana H.; De Vegt, F.; Lakka, Timo A.; Langenberg, Claudia; Launer, Lenore J.; Lind, Lars; Lindström, Jaana; Kahonen, Mika; Liu, Jianjun J.; Liuzzi, Antonio; Lokki, Marja-Liisa; Lorentzon, Mattias; Madden, Pamela A.; Faire, Ulf de; Magnusson, Patrik K.; Manunta, Paolo; Marek, Diana; März, Winfried; Leach, Irene Mateo; März, Winfried; Mcknight, Barbara; Medland, Sarah E.; Mihailov, Evelin; Milani, Lili; Montgomery, Grant W.; Koenig, W.; Mooser, Vincent; Mühleisen, Thomas W.; Munroe, Patricia B.; Musk, Arthur W.; Narisu, Narisu; Mateo Leach, Irene; Navis, Gerjan; Nicholson, George; Nohr, Ellen A.; Ong, Ken Kk; Oostra, Ben A.; Maerz, Winfried; Palmer, Colin N. A.; Palotie, Aarno; Peden, John F.; Pedersen, Nancy; Peters, Annette; Muehleisen, Thomas W.; Polasek, Ozren; Pouta, Anneli; Pramstaller, Peter Pp; Prokopenko, Inga; Pütter, Carolin; C. N. A.,; Radhakrishnan, Aparna; Raitakari, Olli; Rendon, Augusto; Rivadeneira, Fernando; Rudan, Igor; Saaristo, Timo E.; Sambrook, Jennifer G.; Sanders, Alan R.; Sanna, Serena; Saramies, Jouko; Schipf, Sabine; Marz, W.; Schreiber, Stefan; Schunkert, Heribert; Shin, So-Youn; Signorini, Stefano; Sinisalo, Juha; Puetter, Carolin; Skrobek, Boris; Soranzo, Nicole; Stančáková, Alena; Stark, Klaus; Stephens, Jonathan C.; Stirrups, Kathleen; Stolk, Ronald P.; Stumvoll, Michael; Swift, Amy J.; Vegt, Femmie de; Theodoraki, Eirini V.; Thorand, Barbara; Tregouet, David-Alexandre; Muhleisen, T. W.; Tremoli, Elena; van Meurs, Joyce B. Jb; Van Der Klauw, Mm; Van, M. M.; Vermeulen, Sita H.; Viikari, Jorma; Virtamo, Jarmo; J. B. J.,; Vitart, Veronique; Waeber, Gerard; Wang, Zhaoming M.; Van der Klauw, Melanie Mm; Widen, Elisabeth; Wild, Sarah H.; Willemsen, Gonneke; Winkelmann, Bernhard R.; Witteman, Jacqueline C. M.; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Zillikens, Mc Carola; J. C. M.,; Wright, Alan F.; B. H. R.,; Amouyel, Philippe; Boehm, Bernhard O.; Boerwinkle, Eric; H. Vermeulen, Sita; Boomsma, Dorret I.; Caulfield, Mark J.; Chanock, Stephen J.; Cupples, La Adrienne; Cusi, Daniele; Carola Zillikens, M.; Dedoussis, George V.; Erdmann, Jeanette; Eriksson, Johan G.; Franks, Paul W.; Froguel, Philippe; Gieger, Christian; Gyllensten, Ulf; Adrienne Cupples, L.; Hamsten, Anders; Harris, Tamara B.; Hengstenberg, Christian; Hicks, Andrew Aa; Hingorani, Aroon; Hinney, Anke; Hofman, Albert; Hovingh, Kees G.; Hveem, Kristian; Illig, Thomas; Jarvelin, Marjo-Riitta; Jöckel, Karl-Heinz; Keinanen-Kiukaanniemi, Sirkka M.; Kiemeney, Lambertus A. L. M.; Kuh, Diana; Joeckel, Karl-Heinz; Laakso, Markku; Lehtimäki, Terho; Levinson, Douglas F.; Martin, Nicholas G.; Metspalu, Andres; Morris, Andrew D.; Nieminen, Markku S.; Njølstad, Inger; Palmer, Lj J.; Ohlsson, Claes; Oldehinkel, Albertine J.; Ouwehand, Willem H.; Palmer, Lyle J.; Penninx, Brenda; Van Duijn, Cm; Power, Chris; Province, Michael A.; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Vliet-Ostaptchouk, Jana V. Van; Ridker, Paul M.; Ripatti, Samuli; Salomaa, Veikko; Samani, Nilesh J.; Snieder, Harold; T. I. A.,; Van Der Harst, P.; Sørensen, Thorkild I. A.; Spector, Timothy D.; Stefansson, Kari; Tönjes, Anke; Tuomilehto, Jaakko; Sorensen, Thorkild I. A.; Uitterlinden, Andre G.; Uusitupa, Matti; van der Harst, Pim; Tönjes, Anke; Vollenweider, Peter; Wallaschofski, Henri; Der, P. V.; Wareham, Nicholas J.; Watkins, Hugh; Wichmann, He-Erich; Wilson, James F.; Abecasis, Gonçalo R.; Assimes, Themistocles L.; Barroso, Inês; Erich Wichmann, H.; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Frayling, Timothy; Groop, Leif C.; Haritunian, Talin; Heid, Iris M.; Hunter, David; Kaplan, Robert C.; Karpe, Fredrik; Moffatt, Miriam F.; Mohlke, Karen L.; O’connell, Jeffrey R.; O'Connell, Jeffrey R.; Pawitan, Yudi; Schadt, Eric Ee; Schlessinger, David; Steinthorsdottir, Valgerdur; Van, C. M.; Strachan, David P.; Thorsteinsdottir, Unnur; van Duijn, Cornelia M.; Visscher, Peter M.; Di Blasio, Anna Maria; Jockel, K. H.; Hirschhorn, Joel N.; Lindgren, Cecilia M.; Scherag, Andr; Morris, Andrew P.; Meyre, David; Harst, Pim; McCarthy, Mark I.; Speliotes, Elizabeth K.; North, Kari E.; R. J. F.,; Loos, Ruth J. F.; Ingelsson, Erik; O. Connell, Jeffrey R.

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@article{van der Klauw2013,
  abstract = {Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. © 2013 Nature America, Inc. All rights reserved.},
  author = {van der Klauw, M. M. and van Vliet-Ostaptchouk, J. and Berndt, Sonja I. and Gustafsson, Stefan and Mägi, Reedik and Ganna, Andrea and Wheeler, Eleanor and Feitosa, Mary F. and Justice, Anne E. and Monda, Keri L. and Maegi, Reedik and Croteau-Chonka, Damien C. and Day, Felix R. and Esko, Tõnu and E., Anne and Fall, Tove and Ferreira, Teresa and Gentilini, Davide and Ae, Justice and Jackson, Anne U. and Randall, Joshua C. and Vedantam, Sailaja and Magi, R. and Willer, Cristen J. and Mägi, Reedik and Winkler, Thomas W. and Wood, Andrew R. and Workalemahu, Tsegaselassie and Hu, Yi-Juan and Lee, Sang Hong and Luan, Jian An and Liang, Liming M. and Lin, Dan-Yu and Min, Josine L. and Neale, Benjamin M. and Thorleifsson, Gudmar and A. E., Justice and Yang, Jian and Albrecht, Eva and Amin, Najaf and Bragg-Gresham, Jennifer L. and Cadby, Gemma and den Heijer, Martin and Klauw, Melanie M. and Eklund, Niina and Fischer, Krista and Goel, Anuj and Hottenga, Jouke-Jan and Johansson, Åsa and Huffman, Jennifer E. and Jarick, Ivonne and Johansson, Åsa and Johnson, Toby and Kanoni, Stavroula and Johansson, Å. and Kleber, Marcus E. and König, Inke R. and Kristiansson, Kati and Heijer, Martin den and Lamina, Claudia and Müller-Nurasyid, Martina and Lecoeur, Cecile and Li, Guo and Mangino, Massimo and McArdle, Wendy L. and Medina-Gomez, Carolina and Koenig, Inke R. and Müller-Nurasyid, Martina and Ngwa, Julius S. and Nolte, Ilja M. and Paternoster, Lavinia and Pechlivanis, Sonali and Kutalik, Zoltn and Perola, Markus and Peters, Marjolein J. and Preuss, Michael and Rose, Lynda M. and Shi, Jianxin X. and Muller-Nurasyid, M. and Shungin, Dmitry and Smith, Albert Vernon and Strawbridge, Rona J. and Surakka, Ida and Teumer, Alexander and Lavinia, P. and Trip, Mieke D. and Tyrer, Jonathan and Mueller-Nurasyid, Martina and Vandenput, Liesbeth and Waite, Lindsay Ll and Meurs, Joyce B. J. and Zhao, Jing Hua and Absher, Devin and Asselbergs, Folkert W. and Atalay, Mustafa and Attwood, Antony P. and König, Inke R. and Balmforth, Anthony J. and Basart, Hanneke and Beilby, John and Bonnycastle, Lori Ll and Brambilla, Paolo and Van Vliet-Ostaptchouk, Jv and Bruinenberg, Marcel and Campbell, Harry and Chasman, Daniel I. and Chines, Peter S. and Collins, Francis S. and Van, J. V. and Connell, John M. and Cookson, William O. and de Faire, Ulf and de Vegt, Femmie and Dei, Mariano and Duijn, Cornelia M. and Dimitriou, Maria and Edkins, Sarah and Estrada, Karol and Evans, David M. and Farrall, Martin and Van Vliet-Ostaptchouk, Jana V. and Ferrario, Marco Mm and Ferrieres, Jean and Franke, Lude and Frau, Francesca and Gejman, Pablo V. and Groenberg, Henrik and Grallert, Harald and Grönberg, Henrik and Gudnason, Vilmundur and Hall, Alistair S. and Gronberg, H. and Hall, Per and Hartikainen, Anna-Liisa and Hayward, Caroline and Heard-Costa, Nancy L. and Heath, Andrew C. and König, Wolfgang and Hebebrand, Johannes and Homuth, Georg and Hu, Frank B. and Hunt, Sarah E. and Hyppönen, Elina and Hyppoenen, Elina and Iribarren, Carlos and Jacobs, Kevin B. and Jansson, John-Olov and Jula, Antti and Kähönen, Mika and Koenig, Wolfgang and Kathiresan, Sekar and Kee, Frank and Khaw, Kay-Tee and Kivimaki, Mika and O. Cookson, W. and De Faire, U. and Kraja, Aldi T. and Kumari, Meena and Kuulasmaa, Kari and Kuusisto, Johanna and Laitinen, Jaana H. and De Vegt, F. and Lakka, Timo A. and Langenberg, Claudia and Launer, Lenore J. and Lind, Lars and Lindström, Jaana and Kahonen, Mika and Liu, Jianjun J. and Liuzzi, Antonio and Lokki, Marja-Liisa and Lorentzon, Mattias and Madden, Pamela A. and Faire, Ulf de and Magnusson, Patrik K. and Manunta, Paolo and Marek, Diana and März, Winfried and Leach, Irene Mateo and März, Winfried and Mcknight, Barbara and Medland, Sarah E. and Mihailov, Evelin and Milani, Lili and Montgomery, Grant W. and Koenig, W. and Mooser, Vincent and Mühleisen, Thomas W. and Munroe, Patricia B. and Musk, Arthur W. and Narisu, Narisu and Mateo Leach, Irene and Navis, Gerjan and Nicholson, George and Nohr, Ellen A. and Ong, Ken Kk and Oostra, Ben A. and Maerz, Winfried and Palmer, Colin N. A. and Palotie, Aarno and Peden, John F. and Pedersen, Nancy and Peters, Annette and Muehleisen, Thomas W. and Polasek, Ozren and Pouta, Anneli and Pramstaller, Peter Pp and Prokopenko, Inga and Pütter, Carolin and C. N. A.,  and Radhakrishnan, Aparna and Raitakari, Olli and Rendon, Augusto and Rivadeneira, Fernando and Rudan, Igor and Saaristo, Timo E. and Sambrook, Jennifer G. and Sanders, Alan R. and Sanna, Serena and Saramies, Jouko and Schipf, Sabine and Marz, W. and Schreiber, Stefan and Schunkert, Heribert and Shin, So-Youn and Signorini, Stefano and Sinisalo, Juha and Puetter, Carolin and Skrobek, Boris and Soranzo, Nicole and Stančáková, Alena and Stark, Klaus and Stephens, Jonathan C. and Stirrups, Kathleen and Stolk, Ronald P. and Stumvoll, Michael and Swift, Amy J. and Vegt, Femmie de and Theodoraki, Eirini V. and Thorand, Barbara and Tregouet, David-Alexandre and Muhleisen, T. W. and Tremoli, Elena and van Meurs, Joyce B. Jb and Van Der Klauw, Mm and Van, M. M. and Vermeulen, Sita H. and Viikari, Jorma and Virtamo, Jarmo and J. B. J.,  and Vitart, Veronique and Waeber, Gerard and Wang, Zhaoming M. and Van der Klauw, Melanie Mm and Widen, Elisabeth and Wild, Sarah H. and Willemsen, Gonneke and Winkelmann, Bernhard R. and Witteman, Jacqueline C. M. and Wolffenbuttel, Bruce H. R. and Wong, Andrew and Zillikens, Mc Carola and J. C. M.,  and Wright, Alan F. and B. H. R.,  and Amouyel, Philippe and Boehm, Bernhard O. and Boerwinkle, Eric and H. Vermeulen, Sita and Boomsma, Dorret I. and Caulfield, Mark J. and Chanock, Stephen J. and Cupples, La Adrienne and Cusi, Daniele and Carola Zillikens, M. and Dedoussis, George V. and Erdmann, Jeanette and Eriksson, Johan G. and Franks, Paul W. and Froguel, Philippe and Gieger, Christian and Gyllensten, Ulf and Adrienne Cupples, L. and Hamsten, Anders and Harris, Tamara B. and Hengstenberg, Christian and Hicks, Andrew Aa and Hingorani, Aroon and Hinney, Anke and Hofman, Albert and Hovingh, Kees G. and Hveem, Kristian and Illig, Thomas and Jarvelin, Marjo-Riitta and Jöckel, Karl-Heinz and Keinanen-Kiukaanniemi, Sirkka M. and Kiemeney, Lambertus A. L. M. and Kuh, Diana and Joeckel, Karl-Heinz and Laakso, Markku and Lehtimäki, Terho and Levinson, Douglas F. and Martin, Nicholas G. and Metspalu, Andres and Morris, Andrew D. and Nieminen, Markku S. and Njølstad, Inger and Palmer, Lj J. and Ohlsson, Claes and Oldehinkel, Albertine J. and Ouwehand, Willem H. and Palmer, Lyle J. and Penninx, Brenda and Van Duijn, Cm and Power, Chris and Province, Michael A. and Psaty, Bruce M. and Qi, Lu and Rauramaa, Rainer and Vliet-Ostaptchouk, Jana V. Van and Ridker, Paul M. and Ripatti, Samuli and Salomaa, Veikko and Samani, Nilesh J. and Snieder, Harold and T. I. A.,  and Van Der Harst, P. and Sørensen, Thorkild I. A. and Spector, Timothy D. and Stefansson, Kari and Tönjes, Anke and Tuomilehto, Jaakko and Sorensen, Thorkild I. A. and Uitterlinden, Andre G. and Uusitupa, Matti and van der Harst, Pim and Tönjes, Anke and Vollenweider, Peter and Wallaschofski, Henri and Der, P. V. and Wareham, Nicholas J. and Watkins, Hugh and Wichmann, He-Erich and Wilson, James F. and Abecasis, Gonçalo R. and Assimes, Themistocles L. and Barroso, Inês and Erich Wichmann, H. and Boehnke, Michael and Borecki, Ingrid B. and Deloukas, Panos and Fox, Caroline S. and Frayling, Timothy and Groop, Leif C. and Haritunian, Talin and Heid, Iris M. and Hunter, David and Kaplan, Robert C. and Karpe, Fredrik and Moffatt, Miriam F. and Mohlke, Karen L. and O’connell, Jeffrey R. and O'Connell, Jeffrey R. and Pawitan, Yudi and Schadt, Eric Ee and Schlessinger, David and Steinthorsdottir, Valgerdur and Van, C. M. and Strachan, David P. and Thorsteinsdottir, Unnur and van Duijn, Cornelia M. and Visscher, Peter M. and Di Blasio, Anna Maria and Jockel, K. H. and Hirschhorn, Joel N. and Lindgren, Cecilia M. and Scherag, Andr and Morris, Andrew P. and Meyre, David and Harst, Pim and McCarthy, Mark I. and Speliotes, Elizabeth K. and North, Kari E. and R. J. F.,  and Loos, Ruth J. F. and Ingelsson, Erik and O. Connell, Jeffrey R.},
  doi = {10.1038/ng.2606},
  month = {apr},
  title = {Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/23563607},
  year = {2013}
}

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Journal article published in 2013 by M. M. van der Klauw, J. van Vliet-Ostaptchouk, Sonja I. Berndt, Stefan Gustafsson, Reedik Mägi

, Andrea Ganna

, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Reedik Maegi, Damien C. Croteau-Chonka, Felix R. Day

, Tõnu Esko

, Anne E. and other authors. M. M. van der Klauw, J. van Vliet-Ostaptchouk, Sonja I. Berndt, Stefan Gustafsson, Reedik Mägi

, Andrea Ganna

, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Reedik Maegi, Damien C. Croteau-Chonka, Felix R. Day

, Tõnu Esko

, Anne E., Tove Fall, Teresa Ferreira, Davide Gentilini, Justice Ae, Anne U. Jackson, Joshua C. Randall, Sailaja Vedantam, R. Magi, Cristen J. Willer, Reedik Mägi, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Yi-Juan Hu, Sang Hong Lee, Jian An Luan, Liming M. Liang, Dan-Yu Lin, Josine L. Min, Benjamin M. Neale, Gudmar Thorleifsson, Justice A. E., Jian Yang

, Eva Albrecht, Najaf Amin, Jennifer L. Bragg-Gresham, Gemma Cadby, Martin den Heijer

, Melanie M. Klauw, Niina Eklund, Krista Fischer, Anuj Goel, Jouke-Jan Hottenga, Åsa Johansson, Jennifer E. Huffman, Ivonne Jarick, Åsa Johansson, Toby Johnson

, Stavroula Kanoni

, Å. Johansson, Marcus E. Kleber, Inke R. König, Kati Kristiansson, Martin den Heijer, Claudia Lamina, Martina Müller-Nurasyid, Cecile Lecoeur, Guo Li, Massimo Mangino, Wendy L. McArdle, Carolina Medina-Gomez

, Inke R. Koenig, Martina Müller-Nurasyid, Julius S. Ngwa, Ilja M. Nolte, Lavinia Paternoster

, Sonali Pechlivanis, Zoltn Kutalik, Markus Perola, Marjolein J. Peters, Michael Preuss

, Lynda M. Rose, Jianxin X. Shi, M. Muller-Nurasyid, Dmitry Shungin, Albert Vernon Smith

, Rona J. Strawbridge

, Ida Surakka

, Alexander Teumer, P. Lavinia, Mieke D. Trip, Jonathan Tyrer, Martina Mueller-Nurasyid, Liesbeth Vandenput, Lindsay Ll Waite, Joyce B. J. Meurs, Jing Hua Zhao, Devin Absher, Folkert W. Asselbergs, Mustafa Atalay, Antony P. Attwood, Inke R. König, Anthony J. Balmforth, Hanneke Basart, John Beilby, Lori Ll Bonnycastle, Paolo Brambilla, Jv Van Vliet-Ostaptchouk, Marcel Bruinenberg, Harry Campbell, Daniel I. Chasman, Peter S. Chines, Francis S. Collins, J. V. Van, John M. Connell, William O. Cookson, Ulf de Faire, Femmie de Vegt, Mariano Dei, Cornelia M. Duijn, Maria Dimitriou, Sarah Edkins, Karol Estrada, David M. Evans, Martin Farrall, Jana V. Van Vliet-Ostaptchouk, Marco Mm Ferrario, Jean Ferrieres, Lude Franke

, Francesca Frau, Pablo V. Gejman, Henrik Groenberg, Harald Grallert, Henrik Grönberg, Vilmundur Gudnason, Alistair S. Hall, H. Gronberg, Per Hall, Anna-Liisa Hartikainen, Caroline Hayward, Nancy L. Heard-Costa, Andrew C. Heath, Wolfgang König, Johannes Hebebrand, Georg Homuth, Frank B. Hu, Sarah E. Hunt

, Elina Hyppönen

, Elina Hyppoenen, Carlos Iribarren, Kevin B. Jacobs, John-Olov Jansson, Antti Jula, Mika Kähönen

, Wolfgang Koenig, Sekar Kathiresan, Frank Kee, Kay-Tee Khaw, Mika Kivimaki

, W. O. Cookson, U. De Faire, Aldi T. Kraja, Meena Kumari

, Kari Kuulasmaa, Johanna Kuusisto, Jaana H. Laitinen, F. De Vegt, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Lars Lind, Jaana Lindström

, Mika Kahonen, Jianjun J. Liu, Antonio Liuzzi, Marja-Liisa Lokki, Mattias Lorentzon, Pamela A. Madden, Ulf de Faire, Patrik K. Magnusson, Paolo Manunta, Diana Marek, Winfried März, Irene Mateo Leach, Winfried März, Barbara Mcknight, Sarah E. Medland, Evelin Mihailov, Lili Milani, Grant W. Montgomery, W. Koenig, Vincent Mooser, Thomas W. Mühleisen, Patricia B. Munroe, Arthur W. Musk, Narisu Narisu, Irene Mateo Leach, Gerjan Navis, George Nicholson, Ellen A. Nohr, Ken Kk Ong, Ben A. Oostra, Winfried Maerz, Colin N. A. Palmer, Aarno Palotie, John F. Peden, Nancy Pedersen, Annette Peters, Thomas W. Muehleisen, Ozren Polasek, Anneli Pouta, Peter Pp Pramstaller

, Inga Prokopenko

, Carolin Pütter, C. N. A., Aparna Radhakrishnan, Olli Raitakari, Augusto Rendon, Fernando Rivadeneira, Igor Rudan, Timo E. Saaristo, Jennifer G. Sambrook, Alan R. Sanders, Serena Sanna

, Jouko Saramies, Sabine Schipf, W. Marz, Stefan Schreiber, Heribert Schunkert, So-Youn Shin, Stefano Signorini, Juha Sinisalo, Carolin Puetter, Boris Skrobek, Nicole Soranzo, Alena Stančáková, Klaus Stark, Jonathan C. Stephens, Kathleen Stirrups, Ronald P. Stolk, Michael Stumvoll, Amy J. Swift, Femmie de Vegt, Eirini V. Theodoraki, Barbara Thorand, David-Alexandre Tregouet, T. W. Muhleisen, Elena Tremoli, Joyce B. Jb van Meurs

, Mm Van Der Klauw, M. M. Van, Sita H. Vermeulen, Jorma Viikari, Jarmo Virtamo, J. B. J., Veronique Vitart, Gerard Waeber, Zhaoming M. Wang, Melanie Mm Van der Klauw, Elisabeth Widen, Sarah H. Wild, Gonneke Willemsen, Bernhard R. Winkelmann, Jacqueline C. M. Witteman, Bruce H. R. Wolffenbuttel, Andrew Wong, Mc Carola Zillikens, J. C. M., Alan F. Wright, B. H. R., Philippe Amouyel, Bernhard O. Boehm, Eric Boerwinkle, Sita H. Vermeulen, Dorret I. Boomsma, Mark J. Caulfield, Stephen J. Chanock, La Adrienne Cupples

, Daniele Cusi, M. Carola Zillikens, George V. Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Paul W. Franks, Philippe Froguel, Christian Gieger

, Ulf Gyllensten, L. Adrienne Cupples, Anders Hamsten, Tamara B. Harris, Christian Hengstenberg, Andrew Aa Hicks, Aroon Hingorani, Anke Hinney, Albert Hofman, Kees G. Hovingh, Kristian Hveem, Thomas Illig, Marjo-Riitta Jarvelin, Karl-Heinz Jöckel, Sirkka M. Keinanen-Kiukaanniemi, Lambertus A. L. M. Kiemeney, Diana Kuh, Karl-Heinz Joeckel, Markku Laakso, Terho Lehtimäki, Douglas F. Levinson, Nicholas G. Martin

, Andres Metspalu, Andrew D. Morris, Markku S. Nieminen, Inger Njølstad, Lj J. Palmer, Claes Ohlsson, Albertine J. Oldehinkel, Willem H. Ouwehand, Lyle J. Palmer, Brenda Penninx, Cm Van Duijn, Chris Power, Michael A. Province, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Jana V. Van Vliet-Ostaptchouk, Paul M. Ridker, Samuli Ripatti, Veikko Salomaa, Nilesh J. Samani, Harold Snieder, T. I. A., P. Van Der Harst, Thorkild I. A. Sørensen, Timothy D. Spector, Kari Stefansson, Anke Tönjes, Jaakko Tuomilehto, Thorkild I. A. Sorensen, Andre G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Anke Tönjes, Peter Vollenweider, Henri Wallaschofski, P. V. Der, Nicholas J. Wareham, Hugh Watkins, He-Erich Wichmann, James F. Wilson, Gonçalo R. Abecasis, Themistocles L. Assimes, Inês Barroso, H. Erich Wichmann, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas

, Caroline S. Fox, Timothy Frayling, Leif C. Groop, Talin Haritunian, Iris M. Heid, David Hunter, Robert C. Kaplan, Fredrik Karpe

, Miriam F. Moffatt, Karen L. Mohlke, Jeffrey R. O’connell, Jeffrey R. O'Connell, Yudi Pawitan, Eric Ee Schadt, David Schlessinger, Valgerdur Steinthorsdottir

, C. M. Van, David P. Strachan, Unnur Thorsteinsdottir, Cornelia M. van Duijn, Peter M. Visscher, Anna Maria Di Blasio, K. H. Jockel, Joel N. Hirschhorn, Cecilia M. Lindgren, Andr Scherag, Andrew P. Morris, David Meyre, Pim Harst, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, R. J. F., Ruth J. F. Loos, Erik Ingelsson, Jeffrey R. O. Connell

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Abstract

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. © 2013 Nature America, Inc. All rights reserved.

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Abstract