Published in

Oxford University Press (OUP), The Journal of Infectious Diseases, 3(184), p. 355-358

DOI: 10.1086/322035

Links

Tools

Export citation

Search in Google Scholar

Local Interferon‐γ Levels during Respiratory Syncytial Virus Lower Respiratory Tract Infection Are Associated with Disease Severity

Journal article published in 2001 by Louis Bont, Ronnie A. A. M van Diemen‐Steenvoorde, Cobi J. Heijnen, Wim M. C. van Aalderen, Annemieke Kavelaars, Wim M. C van Aalderen, Frank Brus, Jos M. Th M. T. H. Draaisma ORCID, M. Pekelharing Berghuis, R. A. van Diemen Steenvoorde, Jan L. L. Kimpen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

To investigate the role of cell-mediated immunity during respiratory syncytial virus (RSV) infection, interferon (IFN)-gamma and interleukin (IL)-10 levels in nasopharyngeal secretions were measured in infants with lower respiratory tract infection (LRTI) caused by RSV. A novel technique was used to measure in vivo cytokine levels in nasopharyngeal aspirates (NPAs). Cytokine levels in the NPAs of 17 mechanically ventilated infants and 43 nonventilated hospitalized infants were compared. As expected, mechanically ventilated infants were significantly younger than nonventilated infants (7 vs. 14 weeks). IFN-gamma levels were above the limit of detection in the NPAs of 3 (18%) mechanically ventilated infants and in the NPAs of 26 (60%) nonventilated infants. IL-10 levels in the NPAs of mechanically ventilated and nonventilated infants were comparable. It is hypothesized that maturation-related mechanisms have a key role in the development of RSV LRTI that results in mechanical ventilation.