Published in
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
DOI: 10.1109/embc.2013.6609573
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Combination of gene expression and genome copy number alteration has a prognostic value for breast cancer
,
G. Mauri,
M. Ripamonti,
F. Gallivanone,
C. Salvatore,
M. C. Gilardi ,
I. Castiglioni
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Abstract
Specific genome copy number alterations, such as deletions and amplifications are an important factor in tumor development and progression, and are also associated with changes in gene expression. By combining analyses of gene expression and genome copy number we identified genes as candidate biomarkers of BC which were validated as prognostic factors of the disease progression. These results suggest that the proposed combined approach may become a valuable method for BC prognosis.