Published in
Nature Research, Nature Reviews Genetics, 7(14), p. 507-515, 2013
DOI: 10.1038/nrg3457
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Pitfalls of predicting complex traits from SNPs
Journal article published in 2013 by
Naomi R. Wray 
,
Ben J. Hayes,
Jian Yang ,
Alkes L. Price,
Mike E. Goddard,
Peter M. Visscher
,
Ben J. Hayes,
Jian Yang ,
Alkes L. Price,
Mike E. Goddard,
Peter M. Visscher
This paper is made freely available by the publisher.
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Abstract
The success of genome-wide association studies has led to increasing interest in making predictions of complex trait phenotypes including disease from genotype data. Rigorous assessment of the value of predictors is critical before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naïve implementations can lead to severe bias and misinterpretation of results.