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Public Library of Science, PLoS Genetics, 3(9), p. e1003355, 2013

DOI: 10.1371/journal.pgen.1003355

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Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

Journal article published in 2013 by Taeheon Lee, Jian Yang ORCID, Jaemin Kim, Myeong-Chan Cho, Bok-Ghee Han, Jong-Young Lee, Seoae Cho, Hyun-Jeong Lee, Heebal Kim
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent studies in population of European ancestry have shown that 30%∼50% of heritability for human complex traits such as height and body mass index, and common diseases such as schizophrenia and rheumatoid arthritis, can be captured by common SNPs and that genetic variation attributed to chromosomes are in proportion to their length. Using genome-wide estimation and partitioning approaches, we analysed 49 human quantitative traits, many of which are relevant to human diseases, in 7,170 unrelated Korean individuals genotyped on 326,262 SNPs. For 43 of the 49 traits, we estimated a nominally significant (P