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Wiley, Acta Paediatrica: Nurturing the Child, 6(105), p. 576-586, 2016

DOI: 10.1111/apa.13350

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Insulin‐like growth factor 1 has multisystem effects on foetal and preterm infant development

Journal article published in 2016 by Ann Hellström, Linda van Marter, Mirjam van Weissenbruch, David Ley, Ingrid Hansen‐Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda Marter, Mirjam Weissenbruch ORCID, Luca A. Ramenghi ORCID, Kathryn Beardsall, David Dunger, Anna‐Lena Hård, Lois E. H. Smith
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in fetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants. This article is protected by copyright. All rights reserved.