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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(54), p. 1311-1314, 2010

DOI: 10.1128/aac.00946-09

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Inhibition of Porphyromonas gingivalis Biofilm by Oxantel

Journal article published in 2009 by Stuart Dashper ORCID, Ching-Seng Ang, Sze Wei Liu, Rita Paolini, Paul Veith, Eric Reynolds ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.