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Portland Press, Biochemical Journal, 2(425), p. 295-302, 2009

DOI: 10.1042/bj20091352

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Regulation of mRNA cap methylation

Journal article published in 2009 by Victoria H. Cowling ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs ill all eukaryotic organisms ill which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.