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American Chemical Society, Accounts of Chemical Research, 2(43), p. 271-279, 2009

DOI: 10.1021/ar900179t

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Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

Journal article published in 2009 by Jerson L. Silva, Tuane C. R. G. Vieira, Mariana P. B. Gomes, Ana Paula Ano Bom, Luis Mauricio T. R. Lima ORCID, Monica S. Freitas, Daniella Ishimaru, Yraima Cordeiro, Debora Foguel ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Protein misfolding has been implicated in a large number of diseases termed protein- folding disorders (PFDs), which include Alzheimer’s disease, Parkinson’s disease, transmissible spongiform encephalopathies, familial amyloid polyneuropathy, Huntington’s disease, and type II diabetes. In these diseases, large quantities of incorrectly folded proteins undergo aggregation, destroying brain cells and other tissues.