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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(57), p. 3453-3456, 2013

DOI: 10.1128/aac.02454-12

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Genomewide Screen for Modulators of Evolvability under Toxic Antibiotic Exposure.

Journal article published in 2013 by Orsolya Katinka Méhi, Méhi Orsolya, Balázs Bogos, Bálint Csörgő ORCID, Csaba Pál
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Antibiotic resistance is generally selected within a window of concentrations high enough to inhibit wild-type growth but low enough for new resistant mutants to emerge. We studied de novo evolution of resistance to ciprofloxacin in an Escherichia coli knockout library. Five null mutations had little or no effect on intrinsic antibiotic susceptibility but increased the upper antibiotic dosage to which initially sensitive populations could adapt. These mutations affect mismatch repair, translation fidelity, and iron homeostasis.