Lead Optimization of Diarylpyrimidines as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
Journal article published in 2010 by
Zhao-Sen Zeng,
Yong-Hong Liang,
Xiao-Qing Feng,
Fen-Er Chen,
Christophe Pannecouque,
Jan Balzarini,
Erik De Clercq
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Abstract
Antiviral agents: A series of CN-CH2-DAPY analogues were identified as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) against HIV-1. Most of the newly synthesized compounds exhibited strong activity against wild-type HIV-1.