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Elsevier, Bioorganic and Medicinal Chemistry Letters, 3(26), p. 941-945, 2016

DOI: 10.1016/j.bmcl.2015.12.060

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Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Journal article published in 2016 by Gauthier Mark arthur Ndong Ntoutoume, Robert Granet, Jean Pierre Mbakidi, Frédérique Brégier, David Yannick Leger, David Y. Léger, Chloé Fidanzi-Dugas, Vincent Lequart, Nicolas Joly, Bertrand Liagre, Vincent Chaleix, Vincent Sol ORCID
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This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.