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BioMed Central, Journal of Neuroinflammation, 1(13), 2016

DOI: 10.1186/s12974-016-0483-0

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Myeloid dendritic cells are decreased in peripheral blood of Alzheimer’s disease patients in association with disease progression and severity of depressive symptoms

Journal article published in 2016 by Antonio Ciaramella ORCID, Francesca Salani, Federica Bizzoni, Maria Donata Orfei, Carlo Caltagirone, Gianfranco Spalletta, Paola Bossù
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Dendritic cells (DCs) are major orchestrators of immune responses and inflammation. They are migratory cells, which may play a role in Alzheimer's disease (AD), as suggested by prior in vitro studies. With the intent to investigate the clinical relevance of DC modifications in vivo, the present study was aimed to evaluate the levels of blood DCs in AD patients, in relation to the progression of the disease, the severity of its symptoms, and the treatment with acetylcholinesterase inhibitors (AChEIs), a class of drugs used to improve cognitive functioning in people with dementia.