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Elsevier, Tetrahedron: Asymmetry, 24(15), p. 3945-3954

DOI: 10.1016/j.tetasy.2004.11.007

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Enzymatic resolution of (RS)-β-hydroxy selenides in organic media

Journal article published in 2004 by Carlos E. Costa, Giuliano C. Clososki ORCID, Henrique B. Barchesi, Sandra P. Zanotto, M. Graça Nascimento, João V. Comasseto
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This paper is available in a repository.

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Abstract

Kinetic resolutions of a number of β-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS—free Pseudomonas sp. lipase) and CALB (NOVOZYM 435®—immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of temperature, solvent, enzyme immobilization and the structure of the substrates on the resolution is presented.