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Oxford University Press, International Journal of Neuropsychopharmacology, 5(19), p. pyw006, 2016

DOI: 10.1093/ijnp/pyw006

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Frontal D2/3Receptor Availability in Schizophrenia Patients Before and After Their First Antipsychotic Treatment: Relation to Cognitive Functions and Psychopathology

Journal article published in 2016 by Henrik Nørbak-Emig, Bjørn H. Ebdrup, Birgitte Fagerlund ORCID, Claus Svarer, Hans Rasmussen, Lars Friberg, Peter N. Allerup, Egill Rostrup, Lars H. Pinborg ORCID, Birte Y. Glenthøj ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background We have previously reported associations between frontal D2/3 receptor binding potential (BPND), positive symptoms and cognitive deficits in antipsychotic-naïve schizophrenia patients. Here, we examined the effect of dopamine D2/3 receptor blockade on cognition. Additionally, we explored the relation between frontal D2/3 receptor availability (BPND) and treatment effect on positive symptoms.