Extensive research is aimed at improving predictive ability of biogeochemical earth and environmental system simulators, with applications ranging from contaminant transport and remediation to impacts of carbon and nitrogen cycling on local ecosystems and climate. Most process-based numerical models are designed for a single characteristic length and time scale. For application-relevant scales, it is necessary to introduce approximations and empirical parameterizations to describe complex systems because of limitations on process understanding, system characterization and computation. Using emerging understanding of biological and environmental processes at fundamental scales to advance predictions of the larger system behavior requires the development of multiscale simulators, and there is strong interest in coupling microscale and macroscale models together in a hybrid multiscale simulation. A limited number of hybrid multiscale simulations have been developed for biogeochemical systems, mostly using application-specific approaches for model coupling. We are developing a generalized approach to hierarchical model coupling designed for high-performance computational systems, based on the Swift computing workflow framework. In this presentation we will describe the generalized approach and provide two use cases: 1) simulation of a mixing-controlled biogeochemical reaction coupling pore-and continuum-scale models, and 2) simulation of biogeochemical impacts of groundwater – river water interactions coupling fine-and coarse-grid model representations. This generalized framework can be customized for use with any pair of linked models (microscale and macroscale) with minimal intrusiveness to the at-scale simulators. It combines a set of python scripts with the Swift workflow environment to execute a complex multiscale simulation utilizing an approach similar to the well-known Heterogeneous Multiscale Method. User customization is facilitated through user-provided input and output file templates and processing function scripts, and execution within a high-performance computing environment is handled by Swift, such that minimal to no user modification of at-scale codes is required.