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Cell Press, Trends in Genetics, 8(21), p. 436-440

DOI: 10.1016/j.tig.2005.06.003

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Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences

Journal article published in 2005 by Klaudia Walter ORCID, Irina Abnizova, Greg Elgar, Walter R. Gilks
This paper is available in a repository.
This paper is available in a repository.

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Abstract

In a recent study, 1373 highly conserved non-coding elements (CNEs) were detected by aligning the human and Takifugu rubripes (Fugu) genomes. The remarkable degree of sequence conservation in CNEs compared with their surroundings suggested comparing the base composition within CNEs with their 5' and 3' flanking regions. The analysis reveals a novel, sharp and distinct signal of nucleotide frequency bias precisely at the border between CNEs and flanking regions.