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American Chemical Society, Journal of Organic Chemistry, 18(70), p. 7426-7428, 2005

DOI: 10.1021/jo050960+

Wiley-VCH Verlag, ChemInform, 2(37), 2006

DOI: 10.1002/chin.200602099

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Synthesis of Heavily Substituted 1,2-Amino Alcohols in Enantiomerically Pure Form

Journal article published in 2005 by Noemí García-Delgado, Katamreddy Subba Reddy, Lluís Solà, Antoni Riera ORCID, Miquel A. Pericàs ORCID, Xavier Verdaguer
This paper is available in a repository.
This paper is available in a repository.

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Abstract

[reaction: see text] A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.