Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Bugge, Anne; Mandrup, Susanne

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Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

Journal article published in 2010 by Anne Bugge, Susanne Mandrup

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Abstract

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPARα, β/δ, and γ activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.