Purpose: To describe the clinical and histopathologic features of lower lip squamous cell carcinomas (LLSCC) diagnosed over an 11-year period in a referral center for treatment of patients with cancer in the State of Paraíba, and to evaluate possible associations between clinical staging, histologic grade of malignancy, and patients’ characteristics, such as gender, age, race and occupational activity. Methods: A cross-sectional, descriptive-analytical study was performed. The non-probabilistic sample consisted of 58 cases of LLSCC diagnosed in Napoleão Laureano Hospital, João Pessoa-PB, Brazil, between 2000 and 2010. Information regarding gender, age, race, occupation, and clinical stage (TNM) was collected from the patient records. The histopathologic study was based on the histologic grading system proposed by Bryne (1998). The data were analyzed by descriptive statistics and by Fisher’s exact and chi-square tests, with a significance level of 5% (p < 0.05). Results: There was a higher frequency of LLSCC in males (69.0%), with predominance of patients above 60 years old (63.8%). Most patients were white (65.5%) and exerted activities with continuous exposure to solar radiation (74.1%). With respect to the clinical staging, there was a higher frequency of cases in stages II (44.8%) and I (37.9%). Analysis of the histologic grade of malignancy showed a higher proportion of low-grade malignancy tumors (58.6%). No statistically significant associations were found between clinical staging, histologic grade of malignancy, and patients’ features, such as gender, age, race and occupational activity (p > 0.05). Conclusion: During the study period, the clinicopathologic profile of LLSCC in the State of Paraíba did not reveal significant differences in comparison with those reported in other retrospective studies about this neoplasm. © 2014, Association of Support to Oral Health Research (APESB). All rights reserved.