The Greenland ice sheet‘s response to climate change is a major issue in the climate debate. This report reviews existing evidence on how the ice sheet margins reacted to climate change during the past 300,000 years—how it responded to the warm climate of the last interglacial and expanded on to the shelf during the last ice age. Compared to the other large ice sheets in the northern hemisphere, the Greenland ice sheet showed remarkable resilience to temperature change—a good omen for the future.