Renal cell carcinoma (RCC) is the third most common genitourinary malignancy in general population. The incidence of RCC is increasing in the United States, and it is slightly higher among African Americans than the Caucasian population. In 2011, there were approximately 60,920 new cases of kidney cancer reported in the United States (37,120 males and 23,800 females), which resulted in about 13,120 deaths (8,270 males and 4,850 females). RCC is unique among the genitourinary malignancies because close to one third of affected patients show signs and symptoms of a paraneoplastic syndrome (PNS)