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Cold Spring Harbor Perspectives in Biology, 7(3), p. a004952-a004952

DOI: 10.1101/cshperspect.a004952

Encyclopedia of Cancer, p. 1647-1647

DOI: 10.1007/978-3-642-16483-5_2638

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Heparan Sulfate Proteoglycans

Journal article published in 2011 by Takeo Ohnishi, Akihisa Takahashi, Lubomir B. Smilenov, Carol Wicking, Israel Vlodavsky, Laura W. Schrum, Dietrich Schweinitz, John Pierce Wise, Olaf Witt, Umberto Tirelli, Lawrence M. Weiss, Stacey Stein, John Thacker, Philip J. Tofilon, Donna Shewach and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein–heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.