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Elsevier, Tetrahedron Letters, 49(42), p. 8697-8699
DOI: 10.1016/s0040-4039(01)01881-0
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Total synthesis of variolin B
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Abstract
The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. ; http://www.elsevier.com/wps/find/journaldescription.cws_home/233/description#description ; Regan J. Anderson and Jonathan C. Morris