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Public Library of Science, PLoS Neglected Tropical Diseases, 1(10), p. e0004401, 2016

DOI: 10.1371/journal.pntd.0004401

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Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi

Journal article published in 2016 by Daniel M. Bean ORCID, Elizabeth Bilsland, Eileen Devaney, Stephen G. Oliver
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Lymphatic filariasis is caused by the parasitic worms Wuchereria bancrofti, Brugia malayi or B. timori, which are transmitted via the bites from infected mosquitoes. Once in the human body, the parasites develop into adult worms in the lymphatic vessels, causing severe damage and swelling of the affected tissues. According to the World Health Organization, over 1.2 billion people in 58 countries are at risk of contracting lymphatic filariasis. Very few drugs are available to treat patients infected with these parasites, and these have low efficacy against the adult stages of the worms, which can live for 7–15 years in the human body. The requirement for annual treatment increases the risk of drug-resistant worms emerging, making it imperative to develop new drugs against these devastating diseases.