The Use of a Peptidic Scaffold for the Formation of Stable Guanine Tetrads: Control of a H-bonded Pattern in Water
Journal article published in 2011 by
Pierre Murat,
Béatrice Gennaro,
Julian Garcia,
Nicolas Spinelli,
Pascal Dumy 
,
Eric Defrancq
,
Eric Defrancq
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Abstract
With a little help from a scaffold: The pre-organization of guanine units onto a peptidic scaffold allows a remarkable stabilization of the G-quartet motif (see graphic). Indeed, the quartet motif was found to be stable even in water without addition of salts. The present study shows the first formation of a single synthetic G-tetrad under these aqueous conditions.