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Elsevier, Chest Journal, 5(149), p. 1165-1172, 2016

DOI: 10.1016/j.chest.2015.11.012

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Airway Surfactant Protein D Deficiency in Adults With Severe Asthma

Journal article published in 2016 by Rose-Marie A. Mackay, Christopher L. Grainge, Laurie C. Lau, Clair Barber, Howard W. Clark, Peter H. Howarth ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Surfactant protein D (SP-D) is an essential component of the innate immune defence against pathogens within the airways. In addition SP-D regulates allergic inflammation and promotes the removal of apoptotic cells. SP-D dysregulation is evident in several pulmonary diseases. Our aim was to investigate whether airway and serum levels of SP-D are altered in treatment-resistant severe asthma.