Invasive pulmonary aspergillosis (IPA) is rare in patients without underlying immune defects, such as prolonged neutropenia. There have been few reports of IPA complicating influenza infection during the last 60 years. We present 2 more cases of IPA after influenza and review the previous English-language reports of this entity. The cases presented here represent the third and fourth reported cases of IPA associated with 2009 H1N1 influenza infection. This may represent an increased propensity of 2009 H1N1 to facilitate IPA when compared with other strains of influenza.