Addressing issues around the processing of cellulose nanofibres (CNF) composites is important in establishing their use as sustainable, renewable polymer reinforcements. Here, CNF networks of different porosity were made with the aim of increasing their permeability and suitability for processing by vacuum infusion (VI). The CNF networks were infused with epoxy using two different strategies. The permeability, morphology and mechanical properties of the dry networks and the resulting nanocomposites were investigated. Calculated fill-times for CNF networks with 50% porosity were the shortest, but are only less than the gel-time of the epoxy if capillary effects are included. In experiments the CNF networks were clearly wetted. However low transparency indicated that impregnation was incomplete. The modulus and strength of the dry CNF networks increased rapidly with decreasing porosity, but their nanocomposites did not follow this trend, showing instead similar mechanical properties to each other. The results demonstrated that increasing the porosity of the CNF networks to ≈ 50% gives better impregnation resulting in a lower ultimate strength, a higher yield strength and no loss in modulus. Better use of the flow channels in the inherently layered CNF networks could potentially reduce void content in these nanocomposites and thus increase their mechanical properties.