Full text: Download
Pt prodrugs: We synthesized new cationic complexes [PtCl(η2- C2H4) (R,R-chxn)]Cl (1) and [PtCl(η2-C 2H4) (S,S-chxn)] Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin. (Figure Presented)