Published in
Wiley, British Journal of Pharmacology, 23(171), p. 5407-5416, 2014
DOI: 10.1111/bph.12851
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Analgesic tolerance to morphine is regulated by PPARγ
Journal article published in 2014 by
Giordano de Guglielmo,
Marsida Kallupi 
,
Giulia Scuppa ,
Serena Stopponi,
Gregory Demopulos,
George Gaitanaris,
Roberto Ciccocioppo
,
Giulia Scuppa ,
Serena Stopponi,
Gregory Demopulos,
George Gaitanaris,
Roberto Ciccocioppo
This paper is made freely available by the publisher.
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Abstract
Opioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the development of analgesic tolerance to morphine in mice.