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BioMed Central, Journal of Cardiovascular Magnetic Resonance, S1(15), 2013

DOI: 10.1186/1532-429x-15-s1-o82

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Diastolic function from tagged MRI and myocardial fibrosis: the Multi-Ethnic study of Atherosclerosis (MESA)

Journal article published in 2013 by Bharath Ambale Venkatesh ORCID, Anderson C. Armstrong ORCID, Sirisha Donekal, Yuan Chang Liu, Chia-Ying Liu, Kihei Yoneyama ORCID, Colin O. Wu, Marcelo Nacif, Antoinette S. Gomes, W. Gregory Hundley, David A. Bluemke, Joao A. Lima
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

MRI-derived T1 times are associated with diffuse interstitial myocardial fibrosis. LV diastolic dysfunction and fibrosis are important components of cardiac disease, but their relationship has not been firmly established. Early diastolic strain rate (Epeak) has been validated as an indicator of diastolic function by tagged MRI. We derive a novel strain relaxation index (SRI) based on circumferential strain from tagged MRI to indicate early phases of diastolic dysfunction. SRI is defined as the ratio of very early myocardial relaxation time and tissue compliance. We will assess the relationship between diastolic dysfunction assessed by both SRI and Epeak with myocardial fibrosis.