Published in

Impact Journals, Oncotarget, 13(7), p. 15554-15565, 2016

DOI: 10.18632/oncotarget.6952

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Protective effect of α-lipoic acid against radiation-induced fibrosis in mice

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-mediated p300/CBP activity. Thus, α-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF-κB through inhibition of histone acetyltransferase activity. α-LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.