Wiley, European Journal of Organic Chemistry, 6(2000), p. 1013-1018, 2000
DOI: 10.1002/(sici)1099-0690(200003)2000:6<1013::aid-ejoc1013>3.0.co;2-3
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A convenient solid-phase synthesis of oligonucleotides conjugated at the 3′-end with a tetraphenylporphyrin residue, by means of a new polymeric support bearing as a linker a lysine derivative, has been developed. A porphyrin linked 17-mer, designed for antisense experiments, has been prepa- red in good yields, and its hybridization properties with a complementary DNA fragment evaluated by UV thermal analysis.