The present study aimed to assess the antihypertensive efficacy and safety of catheterbased radiofrequency renal sympathetic denervation (RSD) in hypertensive dogs. Furthermore, the study investigated the possible antihypertensive mechanism of radiofrequency RSD through measuring the postoperative serum concentrations of angiotensin II (AngII), nicotinamide adenine dinucleotide phosphate oxidase (NADPHox), malondialdehyde (MDA), nitric oxide (NO) and endothelial NO synthase (eNOS). A total of 12 beagles were randomly divided into the surgery (n=6) and the shamsurgery groups (n=6). The hypertension model was established using a highfat diet. The surgery group received catheterbased radiofrequency RSD, while the shamsurgery group only received renal arteriography. Blood pressure was measured prior to the surgery and 3 days, 1 and 2 weeks, and 1, 2 and 3 months after the surgery. The serum concentrations of AngII, NADPHox, MDA, NO and eNOS were measured prior to the surgery and 1 week, and 1 and 3 months after the surgery. Following the establishment of the model, the systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) of the surgery and the shamsurgery groups were all significantly increased above the baseline (P Document Type: Research Article DOI: http://dx.doi.org/10.3892/br.2014.410 Affiliations: Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China Publication date: January 1, 2015 More about this publication? Biomedical Reports is a new, bimonthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles. Editorial Board Information for Authors Submit a Paper Subscribe to this Title Information for Advertisers Terms & Conditions ingentaconnect is not responsible for the content or availability of external websites $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Biology/Life Sciences , Medicine (General) , Oncology By this author: Jiang ; Li ; Zhu ; Zeng ; Wang ; Wang ; Shen ; Yang ; Zhang GA_googleFillSlot("Horizontal_banner_bottom");