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American Society for Microbiology, Applied and Environmental Microbiology, 13(75), p. 4636-4640, 2009

DOI: 10.1128/aem.00548-09

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High-Level Biosynthesis of the Anteiso-C <sub>17</sub> Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity

Journal article published in 2009 by Patrick Fickers, Jean-Sébastien Guez, Christian Damblon, Valérie Leclère ORCID, Max Béchet, Philippe Jacques, Bernard Joris
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

High-level production (880 mg liter(-1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp. ; Journal Article ; Research Support, Non-U.S. Gov't ; info:eu-repo/semantics/published