Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Communications, 1(6), 2015

DOI: 10.1038/ncomms9658

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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Journal article published in 2015 by Marı́a Soler Artigas, Jing Hua Zhao, Alan F. Wright, Tatijana Zemunik, Eleftheria Zeggini, Louise V. Wain ORCID, M. Soler Artigas, Peter K. Joshi, Wain Lv, Abdul Kader Kheirallah, Suzanne Miller, Jennifer E. Huffman, Lorna M. Lopez, Stefan Enroth ORCID, Ida Surakka and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractLung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.