10.1093/nar/gku1193 INFRAFRONTIER––providing mutant mouse resources as research tools for the international scientific community INFRAFRONTIER Consortium *, ABSTRACT The laboratory mouse is a key model organism to in-vestigate mechanism and therapeutics of human dis-ease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the de-velopment of new, more efficient genome engineer-ing techniques such as CRISPR based systems. We have previously described the European Mouse Mu-tant Archive (EMMA) resource and how this inter-national infrastructure provides archiving and dis-tribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www. infrafrontier.eu), the pan-European research infras-tructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we de-scribe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a compre-hensive knowledgebase and the promotion of inno-vative analytical and diagnostic techniques.